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. Author manuscript; available in PMC: 2021 Mar 3.
Published in final edited form as: Stat Med. 2019 Oct 17;38(28):5299–5316. doi: 10.1002/sim.8361

TABLE 2.

Dose escalation and de-escalation boundaries of the BOIN design

Boundaries Target DLT rate (ϕT)
0.15 0.20 0.25 0.30 0.35 0.40
λe (escalation) 0.118 0.157 0.197 0.236 0.276 0.316
λd (de-escalation) 0.179 0.238 0.298 0.358 0.419 0.480