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PARP-1 inhibition attenuates the microglial morphology changes induced by S100B. Phase contrast micrographs show microglia after incubation with LPS (A) or S100B (B). Representative of 3 experiments; scale bar = 50 μm. The effects of S100B were attenuated by the PARP inhibitor veliparib and in PARP-1−/− microglia (C,D). n = 3, *P < 0.05, **P < 0.01.
