Figure 1.

The patient’s clinical and biological parameters throughout treatment. (A) Urine porphyrins (gray), plasma porphyrins (blue) and ferritin (dark red). (B) Erythrocyte porphyrins (brown), protoporphyrins (light green), coproporphyrins (purple) and uroporphyrins (orange). (C) Hemoglobin (dark blue), reticulocytes (red) and haptoglobin (dark green). At baseline, the urine porphyrins/creatinine ratio ranged from 1845 to 2565 nmol/mmol (reference <30 nmol/mmol), plasma porphyrin concentrations ranged from 227 to 289 nmol/L (reference <20 nmol/L), reticulocyte counts ranged from 115 to 128 x 109/L (reference range, 20-80 x 109/L), the haptoglobin level was 0.16 g/L (reference range, 0.56-2 g/L) and ferritin ranged from 120 to 150 mg/L (reference range, 18-160 mg/L). Over the entire treatment course, ferritin levels were not greater than 17 mg/L.