Figure 2.

Pilot immunogenicity study of codon optimized and wild type S-expressing DNA vaccines. Individual mouse (A–B, N = 6 per group) or monkey (C–F, N = 4 per group) received three DNA immunizations as indicated by arrows using the gene gun delivery approach. The mock group received the empty DNA vaccine vector as the negative control. ELISA titers are shown as the average OD of each group (A, C) or end titration titers at the peak level Day 42 (D). Neutralizing antibody responses (NAb) (B) or IFN-γ (E) and for IL-4 (F) T cell responses are shown from each animal at the peak level on Day 42.