Table 3.

Single-agent treatment with PD-1/PD-L1 immune checkpoint inhibitors in patients with advanced ovarian cancer

Agent	Study Phase	Patient Population	N	Outcomes	Reference
Anti-PD-1 antibodies
Nivolumab	II	Platinum-resistant OvCa	20	ORR, 15%; durable CR in 2 patients; DCR, 45%; mPFS, 3.5 months; mOS, 20 months	Hamanishi et al., 2015
Nivolumab vs gemcitabine or pegylated liposomal doxorubicin	III (NINJA) randomized	Advanced or recurrent platinum-resistant OvCa	316	ORR, 8% v 13%; Duration of reponse: 18.7 v 7.4 months; mPFS, 2.1 v 3.8 months (HR, 1.46; p = .002); mOS: 10.1 v 12.1 months (HR, 1.03; p = .808).	Omatsu et al., 2020
Pembrolizumab	Ib	Advanced OvCa (73.1% of patients with ≥3 prior lines of therapy.	26, PD-L1+	ORR, 11.5%; mPFS, 1.9 months; mOS, 13.8 months	Varga et al., 2019
Pembrolizumab	II	Recurrent OvCa (1–3 prior lines of therapy, PFI/TFI 3–12 months)	285 (cohort A)	ORR, 7.4%; mDOR 8.2 months; DCR, 37.2%; mPFS, 2.1 months; mOS not reached	Matulonis et al., 2019
Pembrolizumab	II	Recurrent OvCa (4–6 prior lines of therapy, PFI/TFI ≥ 3 months)	91 (cohort B)	ORR, 9.9%; mDOR not reached; DCR, 37.4%; mPFS, 2.1 months; mOS 17.6 months	Matulonis et al., 2019
PF-06801591	I	Advanced OvCa	15	ORR, 20%; mPFS, 5.3 months; mOS, not reached	Johnson et al., 2019
Anti-PD-L1 antibodies
Atezolizumab	Ia	Recurrent OvCa	12	ORR, 22%; durable PR in 2 patients; mPFS, 2.9 months; mOS, 11.3 months	Infante et al., 2016; Liu et al., 2019
Avelumab	Ib	Recurrent or refractory OvCa (median 3 prior lines of therapy)	125	ORR, 9.6%; mDOR, 10.4 months; DCR, 42%; mPFS, 2.6 months; mOS, 11.2 months	Disis et al., 2019

CR: complete response, DCR: disease control rate, mDOR: median duration of response, mOS: median overall survival, mPFS: median progression-free survival, OvCa: ovarian cancer, PD-1: programmed death receptor 1, PD-L1: PD ligand 1, PFI: platinum-free interval, PR: partial response, TFI: treatment-free interval.