Figure 1.

Domain organization in LaRP proteins in vertebrates. The domains and motifs are labelled and coloured as follows: La-Motif (LaM, blue), RNA-recognition motif 1 (RRM1, yellow), RNA-recognition motif 2 (RRM2, pink), DM15 domain (green), PAM2w motif (black diagonal stripes), PABP-binding motif (PBM, grey diagonal stripes), RACK-interacting motif (RIR, thin black vertical stripes), short basic motif (SBM, thin black horizontal stripes), La- and S1-associated motif (LSA, solid grey), conserved basic region (CBR, thick black horizontal stripes). Motifs linked to cellular localization are also indicated (NLS, nuclear localization signal; NRE, nuclear retention element; NES, nuclear export signal)