Figure 2.

Comparison of the building blocks in the structures of LaRPs. (A-C) Superposition of the LaM domains of other LaRPs on HsLa (PDB 2VOD, grey). (A) HsLaRP7 (PDB 4WKR, cyan); (B) HsLaRP4 (PDB 6I9B, yellow); (C) HsLaRP6 (PDB 6MTF, magenta). (D-G) The six conserved residues in the cleft of the LaM domains formed by helices α1, α1ʹ, α2 and α3 in (D) HsLa; (E) HsLaRP7; (F) HsLaRP4; (G) HsLaRP6. (H-J) Superposition of the RRM1 domains of other LaRPs on HsLa (PDB 2VOD, grey). (A) HsLaRP7 (PDB 4WKR, cyan); (B) HsLaRP4 (PDB 6I9B, yellow); (C) HsLaRP6 (PDB 2MTG, magenta). The figure was prepared using PyMOL (https://pymol.org/2/)