Figure 1.

Isoforms of LARP1

A) Table of all reported LARP1 isoforms on NCBI (stand 04.11.2019). B) Representative illustration of the exon organization of ‘short’ and ”long” LARP1 isoforms and respective translated proteins. Both isoforms differ in nucleotide/amino acid sequence and length of exon 1 (red). Black squares represent exons. Line represents untranslated regions (UTR). La-module (LAM), RNA recognition motif L5 (RRM-L5) and LARP1 specific DM15 domain are given in orange. C) In silico analysis of expression levels of short and long LARP1 isoforms indicates a prevalent expression of the long isoform in primary cells, tissue and cancer cell lines. Data extracted from ENCODE database and visualized using UCSC Genome browser [23,44]. Also see Supporting Data 1 for a full list of analyzed data