Domain structure and key PTMs of human La protein (hLa, 408 aa)
RRM = RNA Recognition Motif; green box = RiboNucleoProtein (RNP) motif; RCD = RNA chaperone domain (amino acids required for RCD-1 activity are located in the loop 3 and the 53 helix of RRM1) [29,52,53]; NRE = Nuclear Retention Element [31,34,35]; NoLS = Nucleolar Localization Signal [32,33]; NLS = Nuclear Localization Signal [31]; D = Dimerization domain [42]; IDR = Internal Disordered Region [54]; PTM = PostTranslational Modification; S = Sumoylation site [111,113]; P = Phosphorylation site [29,37,100,101].