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. 2021 Feb 28;13(1):1887720. doi: 10.1080/19490976.2021.1887720

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© 2021 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — RNA-sequencing reveals lower expression of negative regulators of inflammation in differentiated Winnie compare to WT organoids. (a), DAVID gene ontology analysis reveals top five pathways/keywords associated with the 119 mostly differentially expressed genes between differentiated Winnie and WT organoids. (b), Heatmap showing expression levels of genes in “Negative regulation of inflammatory response”. (c), mRNA expression of Slpi, Nt5e, Enpp3, Nov, Cxcl11, Cma1 and Calcrl in a separate set of colon organoids isolated from WT and Winnie mice and differentiated with DAPT for 48 h. n = 8 in C per group, each dot represents organoid isolated from one mouse. Mann-Whitney test (*P < .05)