Table 5.
Acetylcholinesterase inhibition by various organophosphates in rat brain.
| Brain Acetylcholinesterase | |||
|---|---|---|---|
| PND 1 | PND 12 | PND 70 | |
| Oxon | IC50 nM (95%CI) | IC50 nM (95%CI) | IC50 nM (95%CI) |
| Azinphos-methyl-oxon | 115 (104,125) | 98 (68,109) | 96 (86,107) |
| Methyl paraoxon | 165 (132,198) | 118 (85,151) | 135 (102,168) |
| Dicapthon-oxon | 175 (144,205) | 131 (101,162) | 139 (108,170) |
| Methyl coumaphos-oxon | 124 (89,160) | 109 (73,144) | 74 (38,109) |
| Paraoxon | 32 (24,39) | 36 (28,44) | 25 (16,32) |
| Chlorpyrifos-oxon | 9 (6,12) | 8 (5,11) | 8 (5,11) |
| Ethyl cyanophos-oxon | 984 (864,1104) | 925 (805,1045) | 784 (664,904) |
| Ethyl ronnel-oxon | 622 (515,729) | 716 (609,822) | 691 (583,798) |
| Diazoxon | 224 (185,264) | 252 (212,291) | 273 (233,312) |
| Naftalophos | 62 (43,81) | 75 (57,94) | 64 (46,83) |
| Nitropyrifos-oxon | 40 (29,52) | 38 (26,49) | 34 (23,46) |
| Phoxim-oxon | 50 (38,63) | 52 (39,64) | 43 (30,55) |
e
IC50s are expressed as means with 95% confidence intervals of three independent replications for each age group. No statistical differences were determined (p < 0.05) among ages.