Table 7.
Butyrylcholinesterase inhibition by various organophosphates in rat serum.
| Serum Butyrylcholinesterase | |||
|---|---|---|---|
| PND 1 | PND 12 | PND 70 | |
| Oxon | IC50 nM (95%CI) | IC50 nM (95%CI) | IC50 nM (95%CI) |
| Azinphos-methyl-oxon | 1051 (931,1382) | 1259 (1181,1337) | 1433 (1176,1691) |
| Methyl paraoxon | 389 (386,392) | 381 (357,406) | 394 (337,452) |
| Dicapthon-oxon | 58 (55,62) | 57 (53,61) | 185* (179,192) |
| Methyl coumaphos-oxon | 1223 (1137,1308) | 1212 (1191,1234) | 1469 (1116,1821) |
| Paraoxon | 47 (46,48) | 52 (50,54) | 76* (58,94) |
| Chlorpyrifos-oxon | 6 (5,7) | 7 (6,7) | 39* (30,49) |
| Ethyl cyanophos-oxon | 208 (167,249) | 224 (180,268) | 339* (282,396) |
| Ethyl ronnel-oxon | 2 (1,3) | 7 (3,8) | 35* (23,48) |
| Diazoxon | 8 (7,9) | 10 (9,11) | 31* (30,33) |
| Naftalophos | 5 (4,6) | 7 (6,7) | 30* (37,43) |
| Nitropyrifos-oxon | 15 (14,16) | 14 (13,15) | 64* (56,73) |
| Phoxim-oxon | 2 (1,3) | 31* (26,36) | 60* (57,64) |
g
IC50s are expressed as means with 95% confidence intervals of three independent replications for each age group. Means for each compound followed by an * are significantly different (p < 0.05) among ages within a tissue.