Figure 4.

A) Gold (Au) content measured by ICP-MS in various tissues 72 h after intravenous injection of gold nanospheres (HAuNS) and HAuNS conjugated with TNYL peptide (TNYL-HAuNS) into nude mice bearing subcutaneous xenografts of rat uterus. B) Expression of EphB4 receptor of healthy mouse uterus, estrogen-treated uterus (e.g., congestive, a term used in the article), and endometriotic lesion by Western blot. Adapted with permission.^[43] Copyright 2017, Wiley-VCH. C) Fluorescence images of various organs and endometriotic lesions resected at 48 h post-injection of non-targeted and hyaluronic acid (HA)-targeted nanoparticles into rats with endometriosis lesions. Endometriosis lesion animal model was created by transplanting autologous fragments of the uterus to the inner surface of the abdominal wall. Adapted with permission.^[61] Copyright 2016, Dovepress.