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. 2021 Feb 25;10(2):bio050096. doi: 10.1242/bio.050096

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© 2021. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 4. — A cartoon illustrating pathways involved in zebrafish embryonic angiogenesis. SHH is a master regulator of angiogenesis and it regulates VEGF/VEGFR2. Neuropilin as a co-receptor is important for VEGF-VEGFR2 interaction and signaling, and regulates Semaphorin-PlexinD1 signaling. VEGFR2 signaling leads to vessel sprouting, whereas PlexinD1 signaling restricts angiogenesis and regulates vessel patterning. VEGFR2 induces regulates Dll4/Notch signaling, which in turn determines vessel specification (EphB4 on vein and EphrinB2 on artery) and vessel stability through Nrarp.