TABLE 2.

Formal assessment of mood effects from DBS.

DBS state (ON medication)	DBS settings	Mood assessment
DBS OFF	NA	Euthymic. No depression, anxiety, or hypomania.
Right DBS lead ON; Left DBS lead OFF	C+;12− (60%);13− (40%);1.0 mA;60 μs;130 Hz	2 min: Patient felt the onset of a profound sadness, sense of hopelessness, despair, and loss of trust. 3 min: Patient started to cry; husband reported a clear change in her eyes. 4 min: Depressed mood became overwhelming: “I feel like I’m pulling away. I feel alone. I don’t see that things will ever get better. I don’t think I could make it.” DBS turned back OFF without warning: Immediately the patient reported “I feel more hopeful. The room seems brighter.” 5 min after DBS turned OFF: Mood reported to be 80% back to baseline.
Right DBS lead OFF; Left DBS lead ON	C+;4−;0.6 mA;60 μs;130 Hz	3 min: Mild increase in right-sided dyskinesia. Mood unchanged, euthymic. No changes in mood during 10 min of monitored stimulation.

DBS, Deep Brain Stimulation; NA, Not Applicable; Min, minutes.