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. 2021 Feb 10;12:632886. doi: 10.3389/fphys.2021.632886

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Copyright © 2021 Hu, Wang, Zhang, Sun and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mechanism of β-arrestin-dependent APJ desensitization and endocytosis. Apelin-36 binds to APJ and forms APJ/apelin-36 complex, which is localized to intracellular lysosome through Rab7 signaling pathway, leading to persistent desensitization of APJ, while apelin-13 forms APJ/apelin-13 complex with APJ and then rapidly circulates APJ to the cell surface through Rab4 signaling pathway, leading to transient desensitization of APJ.