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. 2021 Feb 17;12:637975. doi: 10.3389/fimmu.2021.637975

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Copyright © 2021 Jackson, Ling and Roy.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Human fetal and postnatal B-lymphoid compartments and their immunophenotypes. Dashed outlines indicate cell types that have been described immunophenotypically, but have not yet been characterized by detailed functional and molecular profiling. Faded progenitors, postnatal early lymphoid progenitor (ELP) and PreProB-progenitors are exceedingly rare in adult life. HSC, hematopoietic stem cell; MPP, multi-potent progenitors; LMPP, lymphoid-primed multi-potent progenitors; MLP, multi-lymphoid progenitors; CLP, common lymphoid progenitor. Lin1, lineage cocktail 1: CD2/3/14/19/56/235; Lin2, lineage cocktail 2: CD2/3/14/56/235.