FIGURE 5.

Liraglutide weakened RGCs mitophagy via PINK1/Parkin pathway in vitro. RGCs were respectively treated with normal glucose (25 mmol/L), high glucose (65 mmol/L), high glucose (65 mmol/L), and liraglutide (10 nmol/L) for 24 h. (A) Relative PINK1 and Parkin expression was determined by Western blot. (B,C) Quantification of PINK1 and Parkin expression. (D) Relative LC3A/B and p62 expression was determined by immunocytochemistry. Scale bar: 100 μm. Values are presented as mean ± SEM. n = 3 independent experiments. *p < 0.05, **p＜0.01, ***p < 0.001.