Table 4. Univariate and multivariate analysis of risk factors associated with mortality.

				Univariate analysis		Multivariate analysis
	Category	n	Mortality n (%)	OR (95% CI)	p value	OR (95% CI)	p value
Gender	Male	171	23 (13.5)
	Female	90	15 (16.7)	1.287 (0.634–2.611)	0.484
Age, years	< 63	137	4 (2.9)
	> 63	124	34 (27.4)	12.561 (4.309–36.62)	<0.001	1.142 (1.089–1.197)	<0.001
Hypertension	Yes	131	27 (20.6)
	No	130	11 (8.5)	2.809 (1.328–5.939)	0.005
Cardiovascular disease	Yes	39	14 (35.9)
	No	222	24 (10.8)	4.620 (2.119–10.073)	<0.001
Chronic respiratory disease	Yes	46	13 (28.3)
	No	215	25 (11.6)	2.994 (1.393–6.436)	0.004
Solid Organ Transplantation	Yes	41	5 (12.2)
	No	220	33 (15)	0.787 (0.288–2.152)	0.640
serum C-reactive protein (mg/dL) Day 0	< 8.2	130	15 (11.5)
	>8.2	131	23 (17.6)	1.633 (0.810–3.293)	0.168
serum C-reactive protein (mg/dL), maximum value	< 15.2	130	8 (6.2)
	>15.2	131	30 (23)	4.530 (1.989–10.318)	<0.001	3.068 (1.22–7.71)	0.017
serum Creatinine (mg/dL) Day 0	< 0.9	121	10 (8.3)
	> 0.9	140	28 (20)	2.775 (1.287–5.983)	0.007	3.048 (1.226–7.575)	0.016
Lymphocytes (cell/mm3) Day 0	< 700	133	24 (18)
	>700	128	14 (36.8)	0.558 (0.274–1.134)	0.104
Serum ferritin (ng/mL) Day 0	< 749	124	14 (11.3)
	>749	137	24 (17.5)	1.669 (0.821–3.393)	0.154
D-dimer (ng/mL) Day 0	< 800	140	13 (9.3)
	> 800	121	25 (20.7)	2.544 (1.237–5.230)	0.009
Intensive care unit (ICU) admission	Yes	101	21 (20.8)
	No	160	17 (10.6)	2.208 (1.101–4.427)	0.023
Invasive mechanical ventilation	Yes	53	12 (22.6)
	No	208	26 (12.5)	2.049 (0.955–4.395)	0.062
Septic shock	Yes	56	14 (25)
	No	203	23 (11.3)	2.609 (1.239–5.492)	0.010
Biological therapy	Yes	148	18 (47.4)
	No	113	130 (58.3)	0.644 (0.323–1.284)	0.209
OSDa, baseline
Conventional ward, not requiring supplemental oxygen	Yes	88	5 (5.7)
Conventional ward, requiring supplemental low-flow oxygen	Yes	148	25 (16.9)
ICUb, requiring supplemental high-flow supplemental oxygen	Yes	3	2 (66.7)
ICU, requiring invasive mechanical ventilation/ECMOc	Yes	22	6 (27.3)	15.629	0.001

^aOSD, ordinary scale determination;

^bICU, intensive care unit.

^cECMO, Extracorporeal membrane oxygenation.