Table 1. P-value, Bayes Factor (HBMR) and ΔDIC (BATI) thresholds for Type I error rates (TIER) of 0.05, 0.001 and 1e-04 estimated on 1000GP.
We randomly permuted case and control labels 10 times and for each estimated empirical thresholds for each RVAS test. The median TIER values from 10 random permutations are used as thresholds for benchmark comparison.
| Method (statistical criteria) | 0.05 TIER | 0.001 TIER | 1e-04 TIER |
|---|---|---|---|
| BURDEN (p-value) | 0.0519 | 1.12e-03 | 7.79e-05 |
| KBAC (p-value) | 0.0650 | 1.52e-03 | 1.52e-04 |
| SKAT-O (p-value) | 0.0563 | 1.47e-03 | 1.66e-04 |
| MiST (p-value) | 0.0766 | 2.26e-09 | 3.33e-16 |
| HBMR (Bayes Factor) | 1.2678 | 3.5774 | 9.0838 |
| BATI (ΔDIC) | 2.3898 | 9.5929 | 14.4623 |