Table 3. BATI output of the genetic model estimates for the BRCA1-LoF gene architecture derived from one of the simulations.

Parameter estimates: mean effect (the mean increase of the variant effect on phenotype depending on the variant type, for numerical score CADD indicates the increase of the variant effect for a unit increase of the score), standard deviation of the mean (sd), 95% credible intervals of the mean(CI) and ΔDIC of the genetic model considered in the BATI-based RVAS test.

	BRCA1-LoF architecture
	# variants	mean effect (sd)	95%CI
Missense SNV	26	0.291 (0.463)	(-0.618; 1.199)
LoF SNV	17	0.629 (0.303)	(0.035; 1.225)
CADD	numerical	-0.003 (0.009)	(-0.024; 0.013)
ΔDIC	14.946