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. 2021 Jan 29;115(3):269–280. doi: 10.1093/trstmh/traa193

Figure 4.

Figure 4.

Temporal dynamics of O. volvulus microfilarial prevalence predicted by (A–C) EPIONCHO-IBM and (D–F) ONCHOSIM with a 2-y (2020 and 2021) interruption due to COVID-19 of annual MDA with ivermectin (2017–2030) and remedial annual high-coverage MDA. The pre-intervention (baseline) microfilarial prevalence (in individuals ≥5 y of age) is (A, D) 50%, (B, E) 60%, and (C, F) 70%. Grey lines represent no interruption to MDA and black lines indicate no treatment in 2020 and 2021 but with 2 y of remedial high-coverage MDA in 2024 and 2025. The therapeutic coverage (of the total population) is assumed to be 65%, with the exception of 30% in 2022, 75% in 2024 and 75% in 2025. The proportion of systematic non-participation is set to 5% throughout all simulations.