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. 2021 Feb 20:usab031. doi: 10.1093/milmed/usab031

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Published by Oxford University Press on behalf of the Association of Military Surgeons of the United States 2021. This work is written by (a) US Government employee(s) and is in the public domain in the US.

This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

This work is written by (a) US Government employee(s) and is in the public domain in the US.

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FIGURE 2. — 59MDW amino acid mutations overlaid on spike structure in prefusion conformation. (A-D) Spike protein amino acid mutations were mapped onto the prefusion SARS-CoV-2 spike glycoprotein structure (PDB: 6VSB; Wrapp et al.¹⁹) using PyMOL. Predicted B-cell epitopes (Grifoni et al.²⁰) are shown in black, and 59MDW amino acid changes are shown in gray. Spike protein domains: Yellow = S1 (Note, blue = N-terminal domain [NTD] and green = receptor-binding domain [RBD] are also part of S1); cyan = fusion peptide (FP); red = S2 domain; purple = connector domain; (CD). (E) Diversity of the S protein of SARS-CoV-2 sequenced from 59MDW specimens.