Table 3. Oxaziridine Rearrangement in Continuous-Flow.
| yield (%) |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| entry | reactor | c (mM)a | flow rate (mL min–1) | tR (min)b | t (h)c | 7a | 8a | 7a:8a | productivity (mmol h–1)d | STY (mmol h–1 mL–1)e |
| 1 | A | 11 | 0.30 | 3.6 | 17 | 71 | 12 | 5.9:1 | 0.14 | 0.12 |
| 2 | A | 9 | 0.75 | 1.5 | 26 | 82 | 11 | 7.5:1 | 0.32 | 0.29 |
| 3 | A | 9 | 0.75 | 1.5 | 42 | 84 | 11 | 7.6:1 | 0.33 | 0.30 |
| 4 | B | 9 | 1.20 | 1.8 | 8 | 85 | 10 | 8.5:1 | 0.53 | 0.24 |
a
c = concentration.
b
tR = average retention time.
c
t = time.
d
Productivity = concentration × flow rate × yield × 60.
e
STY is the space-time yield, given by STY = productivity/reactor volume.