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. 2021 Mar 2;33(3):615–628.e13. doi: 10.1016/j.cmet.2021.01.001

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This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Pleiotropic 3q21.1 risk locus association with bone mineral density and fasting glucose levels

(A) Bivariate genetic association with FNBMD and fasting glucose levels for 3p21.1 locus variants. LD in Europeans with the bivariate tag SNP rs2124500 is indicated (1,000 genomes R², dot color). SNPs that meet bivariate criteria are marked by bolded purple dots.

(B) Chromatin state annotations for the 65-kb-long 3p21.1 risk locus across 127 human cell types and tissues (Roadmap Epigenomics Consortium et al., 2015). Chromatin states include Polycomb-repressed states (gray), weak enhancers (yellow), strong enhancers (orange), and transcribed enhancers (lime).