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. 2021 Feb 16;22(2):1096–1105. doi: 10.1093/bib/bbab027

Figure 2.

Figure 2

Examples of mutations that lead to the loss of RNAi-sensitive target sites. Target site for miR-146b-5p (Site 1) (a) and miR-200c-3p (Site 2) (b) in SARS-CoV-2, and sites targeted by miR-99b-5p in SARS-CoV (c) and MERS-CoV (d). The top bar indicates the position of target sites in the orf1ab gene, the three middle rows are the sequences of the target sites in the genome of corresponding strain which are aligned to their open-reading-frame with amino acid sequence labeled above, and the bottom row is the sequence of the miRNA matching the target. Strain names are labeled at the left, and red boxes highlight the mutated nucleotides. Vertical lines above miRNA sequences indicate the matching nucleotide pairs in the miRNAs::target duplexes, and dash lines indicate G–U pairs.