Figure 6.

Data integration process to build a host–SARS-CoV-2 Interactome graph. The building of the integrated host–viral interactome starts with the analysis of the viral genome. Then viral proteins and the interactions with host protein are determined. The determination of such interactions is often performed by integrating experimental data with knowledge extracted from literature. Furthermore, protein structures are also predicted. All of this information (structures, virus–host interactions and viral interactions) is integrated by using heterogeneous networks. The final product of the process is an interactome.