Table 1 ∣.
Summary of dormancy- and reactivation-inducing Factor
| Factor | In vitro data |
In vivo data |
Human data |
Refs. | |
|---|---|---|---|---|---|
| Dormancy inducers | CXCL12 | Y | Y | Y | 65 |
| vWF | Y | Y | N | 23 | |
| TGFβ2 | Y | Y | N | 36 | |
| BMP4, BMP7 | Y | Y | N | 43,48 | |
| Hypoxia | Y | Y | Y | 33 | |
| GAS6 | Y | Y | N | 115,116 | |
| RA | Y | Y | N | 46 | |
| LIF | Y | Y | N | 97 | |
| TSP1 | Y | Y | N | 31 | |
| WNTs | Y | Y | N | 27,117 | |
| DNA methylation repressive chromatin state | Y | Y | Y | 46,72 | |
| Wnt5a | Y | Y | N | 72 | |
| Axolotl embryo | Y | N | N | 86 | |
| miR-126 | Y | Y | Y | 104 | |
| Jagged 1 | Y | Y | N | 118 | |
| Reactivation inducers | COCO | Y | Y | Y | 48 |
| Inflammation and NETs | Y | Y | Y | 32,75,76 | |
| Stiff collagen | Y | Y | N | 79 | |
| Aging | Y | Y | Y | 78,79,119 | |
| VCAM1 | Y | Y | N | 60 | |
| Periostin | Y | Y | N | 31 | |
| TGFβ1 | Y | Y | N | 36 |
Known cancer cell- and microenvironment-derived regulators that promote the dormancy or reactivation of dormant cancer cells in solid and liquid cancers. The type of data available for each factor is also indicated. These findings are compiled from different cancer types and thus these signaling pathways might not all be associated with the dormancy of every type of cancer or microenvironment. Y, yes; N, no.