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. Author manuscript; available in PMC: 2021 Mar 3.
Published in final edited form as: Trends Chem. 2020 Sep 2;2(10):874–887. doi: 10.1016/j.trechm.2020.08.003

Figure 3.

Figure 3.

Exploration of unbiased bicyclic aziridines. (A) Unsucessful Rh-mediated carbene transfer between trans-11a and diazoacetate 9a. (B) Cheletropic extrusion from the Rh-mediated carbene transfer between cis-11a and diazoacetate 9a. (C) Cheletropic extrusion of an aziridinium ylide generated from a copper-mediated carbene transfer. (D) Computed reaction profile for the chelotropic extrusion of the aziridinium ylide formed in the reaction of 11a and dirhodium-bound carbene 9a-Rh2. (E) Computed Wiberg bond indices for the C-N bonds of INT2 and INT2-b.