Skip to main content
. Author manuscript; available in PMC: 2021 Mar 3.
Published in final edited form as: Trends Chem. 2020 Sep 2;2(10):874–887. doi: 10.1016/j.trechm.2020.08.003

Figure 6.

Figure 6.

Intermolecular Rh-catalyzed synthesis of dehydropiperazines. (A) Dehydropiperazine synthesis via the ring expansion of an aziridinium ylide generated from a Rh-mediated carbene transfer. (B) Select dehydropiperazine products from the aziridine and diazoester scopes. (C) Left: Example of an inaccessible alkyl substrate. Right: Computed HOMO and LUMO energies for the bicyclic aziridine, aryl carbene, and alkyl carbene. (D) Computed reaction profile for the ring expansion process involving aziridine 11f and dirhodium-bound carbene 29a-Rh2.