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Initiation of NETs by PRRs. Various DMAPs and cytokines activate NET formation through PRRs. FN-EDA: fibronectin extra domain A; HMGB1: high mobility box group box 1; LRP1: LDL receptor-related protein 1; mtDNA: mitochondrial DNA; PRRs: pattern recognition receptors; RAGE: receptor for advanced glycation end products; ST2: a receptor for IL-33; TLR: Toll-like receptor.
