Table 2.

Best overall response and overall response rate among molecular subtypes

	Pathogenic or likely pathogenic n=56	VUS n=45
Best response, n (%)
Complete response (CR)	2 (4%)	1 (2%)
Partial response (PR)	28 (50%)	5 (11%)
Stable disease	12 (21%)	15 (33%)
Progressive disease	13 (23%)	19 (42%)
Not evaluable	1 (1.8%)	5 (11%)
Overall response (CR+PR), n (%) (95% CI)	30 (54%) (40% to 67%)	6 (13%) (5% to 27%)
OR of CR+PR (95% CI)	7.5 (2.9 to 22.3), p=0.0009	Reference (1.0)

VUS, variants of unknown significance.