Table 4.
Relative normalized mRNA expression of relevant genes in brain tissue. Data are adjusted to aged control group = 100%; n = 10; Displayed are means ± SEM; one-way ANOVA with Dunnett´s multiple comparison post hoc test using oldCon as reference for statistical comparison; normalized to the mRNA expression levels of beta-2-microglobulin (B2M) and phosphoglycerate kinase 1 (PGK1)
| Gene | OldCon [%] |
YouCon [%] |
Wal [%] |
WalEE [%] |
|---|---|---|---|---|
| Synaptophysin | 100 ± 7.6 | 124 ± 8.0 | 99.3 ± 8.6 | 110 ± 6.4 |
| NGF | 100 ± 9.4 | 145 ± 17 | 97.9 ± 18 | 115 ± 13 |
| BDNF | 100 ± 27 | 228 ± 53 | 98.3 ± 28 | 115 ± 28 |
| GAP43 | 100 ± 28 | 111 ± 18 | 86.6 ± 12 | 81.7 ± 13 |
| KEAP1 | 100 ± 11 | 144 ± 21 | 112 ± 18 | 124 ± 14 |
| NRF2 | 100 ± 13 | 152 ± 25 | 89.5 ± 14 | 120 ± 23 |
| CREB1 | 100 ± 8.7 |
144 ± 9.1 * p = 0.0149 |
78.5 ± 15 | 111 ± 6.7 |
| IL1β | 100 ± 17 | 116 ± 20 | 101 ± 20 | 158 ± 36 |
Significance is displayed as: *p < 0.05 (oldCon vs youCon). Parameters for the statistical tests can be found in the supplementary Table S8