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. 2021 Feb 18;8:637580. doi: 10.3389/fvets.2021.637580

Table 1.

List of strata-level data (n = 49) extracted from a total of 24 publications for inclusion in our meta-analysis.

Database # Authors Source Location Tpos Tneg Cpos Cneg BCG dose Route Method Infection measurement method Sample allocation method
101 Wedlock et al. (20)_1 BCG Pasteur 1173P2 New Zealand 9 1 10 0 1–4 × 106 CFU Subcutaneous Experimental Culture Stratified Random Sample
101 Wedlock et al. (20)_2 BCG Danish 1331 New Zealand 8 2 10 0 1–4 × 106 CFU Subcutaneous Experimental Culture Stratified Random Sample
101 Wedlock et al. (20)_3 BCG Danish freeze-dried New Zealand 9 1 10 0 1–4 × 106 CFU Subcutaneous Experimental Culture Stratified Random Sample
120 Buddle et al. (17) BCG Pasteur 1173P2 New Zealand 16 2 7 2 1 × 105 CFU Subcutaneous Experimental Culture Stratified Random Sample
579 Ameni et al. (35) BCG Danish 1331 Ethiopia 14 9 22 4 1–4 × 106 CFU Subcutaneous Natural Culture Random Sample
802 Buddle et al. (16) BCG Pasteur 1173P2 New Zealand 5 4 5 4 5 × 105 CFU Subcutaneous Experimental Culture Random Sample
826 Buddle et al. (14)_1 BCG Pasteur 1173P2 New Zealand 5 11 10 5 6 × 104 CFU Subcutaneous Experimental Culture Not specified
826 Buddle et al. (14)_2 BCG Pasteur 1173P2 New Zealand 4 12 10 5 6 × 106 CFU Subcutaneous Experimental Culture Not specified
828 Buddle et al. (15)_1 BCG Pasteur 1173P2 New Zealand 4 5 6 3 2 × 105 CFU Subcutaneous Experimental Culture Random Sample
828 Buddle et al. (15)_2 BCG Pasteur 1173P2 New Zealand 4 5 6 3 2 × 103 CFU Subcutaneous Experimental Culture Random Sample
828 Buddle et al. (15)_3 BCG Pasteur 1173P2 New Zealand 3 6 6 3 2 × 105 CFU Intratracheal Experimental Culture Random Sample
956 Berggren (13) BCG Glaxo Malawi 75 129 82 128 8–26 × 106 CFU Subcutaneous Natural Culture Alternate calves vaccinated
1065 Wedlock et al. (22) BCG Pasteur 1173P2 New Zealand 5 5 7 3 1 × 106 CFU Subcutaneous Experimental PM Stratified Random Sample
1080 Buddle et al. (21)_1 BCG Pasteur 1173P2 New Zealand 3 7 7 3 1 × 106 CFU Subcutaneous Experimental PM Stratified Random Sample
1080 Buddle et al. (21)_2 BCG Pasteur 1173P2 New Zealand 2 8 7 3 1 × 109 CFU Oral Experimental PM Stratified Random Sample
1080 Buddle et al. (21)_3 BCG Pasteur 1173P2 New Zealand 3 7 7 3 * Subcutaneous and oral Experimental PM Stratified Random Sample
1213 Buddle et al. (18)_1 BCG Pasteur 1173P2 New Zealand 6 4 10 0 1 × 106 CFU Subcutaneous Experimental Culture Random Sample
1213 Buddle et al. (18)_2 BCG Pasteur 1173P2 New Zealand 9 1 10 0 1 × 106 CFU Subcutaneous Experimental Culture Random Sample
1213 Buddle et al. (18)_3 BCG Pasteur 1173P2 New Zealand 8 2 10 0 1 × 106 CFU Subcutaneous Experimental Culture Random Sample
1263 De Klerk et al. (24) BCG Pasteur 1173P2 South Africa 8 6 9 4 3.2 × 107 CFU Intramuscular Combined Culture Random Sample
1266 Ameni et al. (23) BCG Danish 1331 Ethiopia 4 9 11 3 1 × 106 CFU Subcutaneous Natural Culture Random Sample
1296 Thom et al. (28)_1 BCG Danish 1331 UK 6 3 8 1 1–4 × 106 CFU Subcutaneous Experimental Culture Stratified Random Sample
1296 Thom et al. (28)_2 BCG Danish 1331 UK 9 0 9 0 1–4 × 106 CFU Subcutaneous Experimental Culture Stratified Random Sample
1303 Parlane et al. (31)_1 BCG Danish 1331 New Zealand 14 2 16 1 2–8 × 106 CFU Subcutaneous Experimental PM Stratified Random Sample
1303 Parlane et al. (31)_2 BCG Danish 1331 New Zealand 11 4 16 1 2–8 × 106 CFU Subcutaneous Experimental PM Stratified Random Sample
1304 Buddle et al. (29)_1 BCG Danish 1331 New Zealand 2 7 10 0 1–4 × 105 CFU Subcutaneous Experimental PM Stratified Random Sample
1304 Buddle et al. (29)_2 BCG Danish 1331 New Zealand 3 6 10 0 1–4 × 106 CFU Subcutaneous Experimental PM Stratified Random Sample
1337 Buddle et al. (33) BCG Danish 1331 New Zealand 6 6 7 5 1.5 × 106 CFU Subcutaneous Experimental PM Stratified Random Sample
1358 Nugent et al. (34)_1 BCG Danish 1331 New Zealand 0 30 8 122 1 × 108 CFU Oral Natural PM Random Sample
1358 Nugent et al. (34)_2 BCG Danish 1331 New Zealand 1 33 8 122 3 × 105 CFU Subcutaneous Natural PM Random Sample
1358 Nugent et al. (34)_3 BCG Danish 1331 New Zealand 3 169 9 108 1 × 108 CFU Oral Natural PM Random Sample
1358 Nugent et al. (34)_4 BCG Danish 1331 New Zealand 11 166 12 74 1 × 108 CFU Oral Natural PM Random Sample
1358 Nugent et al. (34)_5 BCG Danish 1331 New Zealand 12 156 26 83 1 × 108 CFU Oral Natural PM Random Sample
1358 Nugent et al. (34)_6 BCG Danish 1331 New Zealand 4 93 8 81 1 × 108 CFU Oral Natural PM Random Sample
1366 Buddle et al. (19)_1 BCG Pasteur 1173P2 New Zealand 6 4 9 1 1 × 108 CFU Oral Experimental PM Stratified Random Sample
1366 Buddle et al. (19)_2 BCG Pasteur 1173P2 New Zealand 7 3 9 1 1 × 109 CFU Oral Experimental PM Stratified Random Sample
1366 Buddle et al. (19)_3 BCG Pasteur 1173P2 New Zealand 5 5 9 1 1 × 106 CFU Subcutaneous Experimental PM Stratified Random Sample
1371 Hope et al. (27)_1 BCG Danish 1331 UK 7 0 7 0 2 × 106 CFU Subcutaneous Experimental PM and Culture Not specified
1371 Hope et al. (27)_2 BCG Pasteur 1173P2 UK 3 4 7 0 2 × 106 CFU Subcutaneous Experimental PM and Culture Not specified
1373 Lopez-Valencia et al. (25) BCG Tokyo Mexico 6 59 15 51 1 × 106 CFU Subcutaneous Natural Skin test and IFNg assay Alternate calves vaccinated
1379 Buddle et al. (26)_1 BCG Danish 1331 New Zealand 2 7 6 4 1 × 106 CFU Subcutaneous Experimental PM Stratified Random Sample
1379 Buddle et al. (26)_2 BCG Danish 1331 New Zealand 5 4 6 4 1 × 108 CFU Oral Experimental PM Stratified Random Sample
1379 Buddle et al. (26)_3 BCG Danish 1331 New Zealand 5 4 6 4 1 × 107 CFU Oral Experimental PM Stratified Random Sample
1379 Buddle et al. (26)_4 BCG Danish 1331 New Zealand 6 3 6 4 1 × 106 CFU Oral Experimental PM Stratified Random Sample
1383 Dean et al. (30) BCG Danish 1331 UK 4 6 9 1 1 × 106 CFU Subcutaneous Experimental Culture Not specified
1385 Dean et al. (32)_1 BCG Danish 1331 UK 8 2 8 1 1 × 106 CFU Subcutaneous Experimental Culture Random Sample
1385 Dean et al. (32)_2 BCG Danish 1331 UK 5 5 8 1 5 × 105 CFU Subcutaneous and endobronchial Experimental Culture Random Sample
1385 Dean et al. (32)_3 BCG Danish 1331 UK 5 5 8 1 1 × 106 CFU Endobronchial Experimental Culture Random Sample
1410 Nugent et al. (36) BCG Danish 1331 New Zealand 2 518 8 289 3 × 105 CFU Subcutaneous Natural PM and Culture Block Randomization
*

Buddle et al. (21)_3 used a combination of Oral and Subcutaneous BCG; Study no. 1263 (24) was performed in buffaloes. Tpos and Cpos are animals classified as positive for bTB in vaccinates and controls, respectively. Tneg and Cneg are animals that remained negative for bTB in vaccinates and controls, respectively.

Multiple strata level data extracted from a single study are represented with numbers at the end in the Author column. For example, Database #101, Wedlock et al had 3 strata level data represented as Wedlock et al._1, Wedlock et al._2 and Wedlock et al._3. Buddle_a is Reference (14) and Buddle_b is Reference (15). a1, a2, and b1, b2 are strata level data of those respective studies.