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. 2021 Mar 3;11:5058. doi: 10.1038/s41598-021-84590-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Chemical similarity enrichment analysis of metabolomic data highlighting the differential metabolic regulation in the intracellular medium (A) and extracellular medium (B) after incubation of HK-2 cells in HG (25 mM glucose)-hypoxia (1% O₂) compared to control (5.5 mM glucose/18.6% O₂) conditions for 48 h. Statistical enrichment analysis utilized chemical similarity and ontology mapping to generate metabolite clusters. The y-axis shows most significantly altered clusters on top, x-axis shows XlogP values of metabolite clusters. Cluster colors give the proportion of increased or decreased compounds (red = increased, blue = decreased) in each cluster. Chemical enrichment statistics is calculated by Kolmogorov–Smirnov test. Only enrichment clusters are shown that are significantly different at p < 0.05. Plots and calculations were done using ChemRICH.