Table 1.

Clinical characteristics of individuals included in the study at baseline.

	Healthy N = 34	Localized N = 112	mCRPC N = 122
Age (years)
Median ± IQR	60 ± 17	65 ± 10	71 ± 9
Range	41–74	43–78	47–91
Pathologic Gleason*
6	–	6	–
7	–	75	–
8–10	–	30	–
Pathologic stage
Organ confined (pT2)	–	46	–
Not organ confined (pT3, pT4)	–	66	–
Extraprostatic extension (pT3a)	–	43	–
Seminal vesicle invasion (pT3b)	–	15	–
Lymph node involvement (N1)	–	17	–
PSA (ng/mL)
Median ± IQR	–	6.9 ± 7.4	50.8 ± 128
Range	–	1.21–70.0	0–3007
cfDNA concentration (ng/mL)†
Median ± IQR	7.9 ± 4.0	6.7 ± 5.8	13.8 ± 28.1
Range	0.29–16.9	1.22–53.9	1–1380
cfDNA fragment size (bp)
Median ± IQR	177.5 ± 29.5	173 ± 6	–
Range	142–265	135–280	–

*One man with unknown data in the cohort.

^†Concentration data collected on a subset of individuals (31 healthy, 45 localized, and 122 mCRPC).