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. 2021 Mar 3;11:5085. doi: 10.1038/s41598-021-84106-y

Figure 3.

Figure 3

Loss of LOTUS decreases spine density in the hippocampal CA1 region. (a) LOTUS controls the dendritic spine in apical dendrites. Scale bars, 1 µm. (b) Quantification of the spine density in apical dendrites of hippocampal neurons in the CA1 region; 41 − 43 dendrites were analyzed in each mouse (WT: n = 3; LOTUS-KO: n = 3). Data are means ± SEM from **P < 0.01, ***P < 0.001. Student’s unpaired t-test. (c) LOTUS controls the dendritic spine in basal dendrites. Scale bars, 1 µm. (d) Quantification of the spine density in basal dendrites of hippocampal neurons in the CA1 region; 40 − 44 dendrites were analyzed in each mouse (WT: n = 3; LOTUS-KO: n = 3). Data are means ± SEM from *P < 0.05, ***P < 0.001, Student’s unpaired t-test.