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. 2021 Mar 3;11:5085. doi: 10.1038/s41598-021-84106-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Loss of LOTUS causes impairment in social cognitive memory. (a) Comparison of the social investigation time during 3 min of exposure time. Data are means ± SEM from WT mice (n = 9) and LOTUS-KO mice (n = 10). ***P < 0.001, Day1 versus Day2, Student’s paired t-test, WT mice versus LOTUS-KO mice, Student’s unpaired t-test. (b) Recognition index. Data are means ± SEM from WT (n = 9) and LOTUS-KO (n = 10) mice. ***P < 0.001, Student’s unpaired t-test.