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. 2021 Mar 3;11:5022. doi: 10.1038/s41598-021-83185-1

Table 2.

Top differentially methylated loci in the comparison between patients with asthma and COPD overlap (ACO) and healthy non-smokers (comparison I) in the discovery cohort.

Column ID UCSC RefGene Name UCSC RefGene Accession UCSC RefGene Group P value q value Mean difference 0f. β value
cg16093065 TNRC6B NM_001162501 3′UTR 0.000430942 0.174101 0.179
cg07674304 WWOX NM_016373 Body 0.000215471 0.0870503 0.173
cg14150023 TNRC6B NM_001162501 3′UTR 0.000215471 0.0870503 0.159
cg13828808 ROR2 NM_004560 Body 0.000430942 0.174101 0.137
cg19421218 TIGIT NM_173799 TSS200 0.000107735 0.0435249 0.132
cg26601310 PRR5L NM_001160167 5′UTR 0.000215471 0.0870503 0.131
cg14392772 TRAF1 NM_005658 3′UTR 0.000430942 0.174101 0.127
cg24450112 PDE9A NM_001001582 Body 0.000430942 0.174101 0.119
cg22027471 SLC5A4 NM_014227 TSS1500 0.000430942 0.174101 0.115
cg05757530 NLRC5 NM_032206 5′UTR 0.000430942 0.174101 0.113
cg07563400 ADORA2B NM_000676 Body 0.000215471 0.0870503 − 0.116
cg17278447 NPTX2 NM_002523 Body 0.000430942 0.174101 − 0.116
cg22422264 USP50 NM_203494 3′UTR 0.000430942 0.174101 − 0.116
cg13676763 FAM125B NM_033446 Body 0.000430942 0.174101 − 0.118
cg03707168 PPP1R15A NM_014330 Body 0.000430942 0.174101 − 0.119
cg13334727 SEPT8 NM_001098813 TSS200 0.000215471 0.0870503 − 0.119
cg14459011 NHEDC2 NM_178833 TSS1500 0.000107735 0.0435249 − 0.121
cg20861489 HCRTR2 NM_001526 Body 0.000430942 0.174101 − 0.122
cg01534527 CTDSPL NM_005808 Body 0.000215471 0.0870503 − 0.123
cg12655112 EHD4 NM_139265 Body 0.000430942 0.174101 − 0.123
cg07568296 MAD1L1 NM_003550 Body 0.000430942 0.174101 − 0.123
cg15243578 PITPNM2 NM_020845 3′UTR 0.000430942 0.174101 − 0.124
cg08510456 BSN NM_003458 TSS1500 0.000430942 0.174101 − 0.125
cg15545247 GPR109B; NM_006018 1stExon 0.000430942 0.174101 − 0.125
cg02853948 HCRTR2 NM_001526 Body 0.000430942 0.174101 − 0.125
cg20705781 SSH3 NM_017857 TSS1500 0.000430942 0.174101 − 0.125
cg18200150 MYO1D NM_015194 Body 0.000107735 0.0435249 − 0.126
cg04658021 PER1 NM_002616 TSS1500 0.000430942 0.174101 − 0.127
cg01376079 SSH3 NM_017857 TSS1500 0.000215471 0.0870503 − 0.127
cg07987148 TP53RK NM_033550 TSS1500 0.000430942 0.174101 − 0.127
cg18688704 PDGFC NM_016205 Body 0.000430942 0.174101 − 0.129
cg07180646 TMEM51 NM_001136218 5′UTR 0.000430942 0.174101 − 0.13
cg22331200 MPO NM_000250 Body 0.000430942 0.174101 − 0.134
cg06487194 JARID2 NM_004973 Body 0.000430942 0.174101 − 0.135
cg22499893 SFRS13A NM_054016 TSS1500 0.000215471 0.0870503 − 0.135
cg01394781 ABCC1 NM_019862 Body 0.000430942 0.174101 − 0.137
cg12401918 NOTCH4 NM_022107 TSS1500 0.000430942 0.174101 − 0.137
cg06815976 NOTCH4 NM_004557 Body 0.000430942 0.174101 − 0.137
cg15529344 ANKRD58 NM_001105576 TSS1500 0.000430942 0.174101 − 0.138
cg26337070 ATOH8 NM_032827 Body 0.000430942 0.174101 − 0.143
cg24892069 NRP1 NM_001024628 Body 0.000215471 0.0870503 − 0.146
cg02607972 ASXL2 NM_018263 3′UTR 0.000430942 0.174101 − 0.147
cg01836137 INF2; NM_022489 5′UTR 0.000430942 0.174101 − 0.152
cg11615395 MAML3 NM_018717 Body 0.000107735 0.0435249 − 0.152
cg05655915 NARF NM_012336 TSS1500; 0.000430942 0.174101 − 0.152
cg00813999 CYSLTR1 NM_006639 1stExon 0.000430942 0.174101 − 0.153
cg19351604 ARHGEF10 NM_014629 Body 0.000430942 0.174101 − 0.154
cg05413628 CLCN7 NM_001287 Body 0.000430942 0.174101 − 0.157
cg01870865 TREX1 NM_016381 TSS200 0.000215471 0.0870503 − 0.159
cg25918947 TMEM106A NM_145041 Body 0.000430942 0.174101 − 0.16
cg07375836 ACACA NM_198839 5′UTR 0.000430942 0.174101 − 0.165
cg26746309 ERLIN1 NM_001100626 Body 0.000215471 0.0870503 − 0.165
cg14481208 RTKN NM_001015055 TSS1500 0.000430942 0.174101 − 0.165
cg09841842 FRMD6 NM_001042481 5′UTR 0.000215471 0.0870503 − 0.166
cg08223235 BCL2 NM_000633 Body 0.000215471 0.0870503 − 0.167
cg20981848 BTBD3 NM_014962 Body 0.000215471 0.0870503 − 0.167
cg10718056 TRIM27 NM_006510 Body 0.000430942 0.174101 − 0.167
cg19628988 CXXC5 NM_016463 5′UTR 0.000430942 0.174101 − 0.169
cg21141827 ETF1 NM_004730 3′UTR 0.000215471 0.0870503 − 0.179
cg17514528 MTHFR NM_005957 Body 0.000215471 0.0870503 − 0.184
cg16672562 HIF3A NM_022462 1st Exon 0.000430942 0.174101 − 0.226
cg10288111 IFRD1 NM_001007245 TSS1500 0.000430942 0.174101 − 0.243
cg11307715 DENND3 NM_014957 Body 0.000430942 0.174101 − 0.361

UTR un-translated region; TSS transcription start site.