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. 2021 Mar 3;12:1424. doi: 10.1038/s41467-021-21592-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a QQ-plot of nominal p-values for a random subset (size = 96,660) of cis-eQTLs (FDR < 0.05) reported in eQTLGen. b QQ-plot of nominal p-values for a random subset (size = 78,691) of variant/gene pairs with p-value > 0.5 in eQTLGen. c χ² statistics from eQTL analysis (x-axis) and mixQTL analysis (y-axis) among a random subset (size = 96,660) of cis-eQTLs (FDR < 0.05) reported in eQTLGen. Two randomly selected genes (ENSG00000115607 and ENSG00000213462) are highlighted in red and green, respectively. d, e ROC and PR curves for mixQTL and the standard eQTL method measured in eQTLGen. Each panel shows the results of genes stratified by expression level tertiles.