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Criteria for the diagnosis of dysplasia using probe-based confocal laser endomicroscopy (pCLE) and hematoxylin-and-eosin-stained biopsies.
| pCLE Criteria for Dysplasia31,33 | Biopsy Criteria for Dysplasia34 |
|---|---|
| Enlarged, irregular cells | Distorted gland architecture |
| Glands vary in size and spacing | Gland crowding |
| Crowded glands | Pleomorphism |
| Variable epithelium thickness | Enlarged nuclei |
| Saw-toothed epithelium | Mitotic activity |
| Relative lack of goblet cells | Hyperchromasia |
