Table 3.

Variance in the thickness of retinal nerve fiber layer (μm) in the group administered intravitreal aflibercept injection.

	Treated eye	Fellow eye	p valuea
Global RNFL
Baseline	97.39 ± 18.61	94.33 ± 17.96	0.281
Third month	95.43 ± 18.04	92.83 ± 18.56	0.354
Sixth month	96.75 ± 15.03	95.04 ± 14.54	0.399
Twelfth month	94.54 ± 17.71	93.58 ± 18.84	0.755
p valueb	0.023*	0.831
Superior temporal sector RNFL
Baseline	128.07 ± 32.63	125.74 ± 30.86	0.459
Third month	126.11 ± 33.18	122.38 ± 30.62	0.317
Sixth month	129.96 ± 23.90	124.91 ± 20.00	0.208
Twelfth month	125.54 ± 32.76	122.85 ± 28.64	0.336
p valueb	0.406	0.578
Temporal sector RNFL
Baseline	79.89 ± 20.71	75.19 ± 16.42	0.533
Third month	73.64 ± 16.86	72.33 ± 17.28	0.993
Sixth month	72.86 ± 15.75	74.00 ± 15.20	0.762
Twelfth month	74.39 ± 18.08	73.62 ± 16.42	0.952
p valueb	0.134	0.870
Inferior temporal sector RNFL
Baseline	135.57 ± 38.87	137.04 ± 36.83	0.637
Third month	135.07 ± 38.58	134.75 ± 38.22	0.526
Sixth month	140.54 ± 30.38	141.00 ± 32.21	0.740
Twelfth month	132.32 ± 38.48	135.46 ± 41.02	0.856
p valueb	0.057	0.394
Inferior nasal sector RNFL
Baseline	109.50 ± 31.15	104.44 ± 29.86	0.474
Third month	112.61 ± 28.50	105.25 ± 32.15	0.321
Sixth month	111.50 ± 23.79	106.43 ± 24.69	0.684
Twelfth month	108.68 ± 28.11	105.88 ± 29.93	0.835
p valueb	0.932	0.445
Nasal sector RNFL
Baseline	69.89 ± 16.66	67.30 ± 12.17	0.292
Third month	69.82 ± 15.49	67.29 ± 11.44	0.195
Sixth month	70.18 ± 14.28	68.35 ± 12.75	0.495
Twelfth month	69.00 ± 14.45	66.73 ± 13.85	0.420
p valueb	0.450	0.700
Superior nasal sector RNFL
Baseline	105.11 ± 29.90	102.33 ± 24.58	0.414
Third month	102.82 ± 29.62	100.33 ± 24.59	0.563
Sixth month	106.14 ± 25.31	103.70 ± 23.01	0.576
Twelfth month	102.64 ± 30.12	102.92 ± 24.54	0.869
p valueb	0.100	0.779

RNFL retinal nerve fiber layer.

^aComparison between the treated eyes and fellow eyes in each period (Mann–Whitney U-test).

^bComparison between the baseline and twelfth month for each value (Wilcoxon signed-rank test).

* p <.05.