Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Intracellular signaling due to changes in blood pressure in the varicose vein. Changes in mechanical stress in the varicose vein can be transmitted into the cell through an extracellular matrix dependent on integrins, ion channels, or AT1R. The resulting changes can eventually cause remodeling in vein structure, inflammation, hypoxia, and vasoconstriction
