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. 2021 Mar 3;11:5103. doi: 10.1038/s41598-021-84553-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The average number of HRF in different retinal layers at the baseline and 3, 6, 12 months after anti-vascular endothelial growth factor treatment for diabetic macular oedema. The number of HRF in every retinal layer significantly decreased in all follow up time points compared with baseline. HRF hyperreflective foci, SRF subretinal fluid. *p = 0.001 (compared with baseline). ^#p = 0.002 (compared with baseline). **p < 0.001 (compared with baseline).