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. 2021 Feb 18;15:627110. doi: 10.3389/fnins.2021.627110

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Copyright © 2021 Liu, He, Wu, Du, Jiang, Chen, Yu, Zhong, Wang, Cheng, Sun and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of Y27632 on endothelial function after CCI. (A) Representative bands and quantitative analysis of the expressions of occludin, VE-cadherin, claudin-5, and ZO-1 at 24 h after CCI. Y27632 preserved the expression levels of occludin, ZO-1, and VE-cadherin (p < 0.05), rather than claudin-5 (p > 0.05). (B) Representative bands and quantitative analysis of the expressions of endothelial molecules at 72 h after CCI. The endothelial molecules from isolated microvessels were analyzed. The protein levels of VCAM-1, ICAM-1, and CD99 were significantly suppressed by Y27632 treatment (p < 0.05). Relative density of each protein was normalized to the sham group. *p < 0.05 vs. sham, #p < 0.05 vs. vehicle, n = 5 per group.