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. 2021 Mar 3;11:5107. doi: 10.1038/s41598-021-84492-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Protein analysis of secreted LOX in monolayer cultures not treated and treated with all formulations, full-length blots/gels are presented in Supplementary Fig. 2A. (B) Protein analysis of secreted LOX in 3D cultures not treated and treated with all formulations, full-length blots/gels are presented in Supplementary Fig. 2B, C. (C) Confocal analysis of 3D cultures exposed to formulations encapsulated with anthracycline after 6 h from the exposure. Nuclei were stained with dapi (blue), actin filaments were stained with phalloidin (green), epirubicin (red) and merge. (D) Confocal analysis of 3D cultures exposed to formulations encapsulated with anthracycline after 48 h from the exposure. Scale bar 50 µm (E) Mean fluorescence intensity of anthracycline detected after 6 and 48 h. (F) Cell viability of tumor cells after treatment with all studied formulations in standard monolayer cultures, negative control is CTR and positive control is LIPO-EPI-LOX. (G) Cell viability of tumor cells after treatment with all studied formulations in 3D cultures, negative control is CTR and positive control is LIPO-EPI-LOX. *p < 0.05, **p < 0.01.