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. 2021 Mar 3;11:5107. doi: 10.1038/s41598-021-84492-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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(A) In vivo biodistribution analysis of Lipo-EPI and Lipo-EPI-LOX in orthotropic xenograft mouse model of human TNBC at different time points (0, 1, 2 and 24 h post injections). (B) bioluminescence and fluorescence analysis of explanted organs (liver, spleen, lungs, heart, kidneys, tumors) to detect EPI localization. (C) Lipo-EPI and Lipo-EPI-LOX fluorescent signal quantification in tumor. (D) Lipo-EPI and Lipo-EPI-LOX fluorescent signal quantification in explanted organs.