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. 2021 Mar 3;11:5107. doi: 10.1038/s41598-021-84492-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Tumor growth curves of orthotopic xenograft mouse model of human TNBC. Five group mice (n = 10 each group) treated with empty liposome (CTR), Lipo-LOX, LIPO-EPI, free EPI and Lipo-EPI-LOX. (B) Delta quantification of TNBC bioluminescent signal after 4 weeks of treatment. (C) Representative example of H&E stained sections of explanted tumors 55 days post treatment. Control: markedly atypical and pleomorphic cells (5% necrotic tumor cells). Scale bar is 400 µm. Lipo-LOX: fibrotic tissue with atypical cells and neoplastic crown (25% necrotic tumor cells). Lipo-EPI: Neoplastic cells and necrotic bands (50% necrotic tumor cells). Free EPI: tumor cells infiltrating adipose tissue with minimal necrotic features e limited inflammation (20% necrotic tumor cells). Lipo-EPI-LOX : tumor cells infiltrating adipose tissue with artifacts (60% necrotic tumor cells). Representative example of collagen stained sections of explanted tumors 55 days post treatment. Control: collagen fibers linearization ˃ 200 µm, Lipo-LOX collagen fibers linearization ˂ 200 µm, Lipo-EPI collagen fibers linearization ˃ 200 µm, free EPI collagen fibers linearization ˃ 200 µm, Lipo-EPI-LOX collagen fibers linearization ˂ 200 µm. Scale bar is 400 µm. (D) Kaplan–Meier curve indicating survival in tumor-bearing mice after tumor induction in the listed treatment groups (Control, Lipo-LOX, LIPO-EPI, free EPI and Lipo-EPI-LOX).