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. 2021 Mar 3;11:5107. doi: 10.1038/s41598-021-84492-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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(A) body weight change percentage of mice at the end of the study. (B) Representative example of H&E stained sections of explanted hearts 55 days post treatment. Control: normal cardiac tissue. Lipo-LOX: no increase of inflammatory infiltrate. Lipo-EPI: minimal focal increase of inflammatory infiltrate (granulocytes and lymphocytes), artifacts. Free EPI: increased cellularity due to possible inflammatory infiltrate. Lipo-EPI-LOX : no significant increment of lymphoid infiltrate, artifacts. Scale bar is 400 µm. Representative example of H&E stained sections of explanted lungs 55 days post treatment. Control: phlogosis 70%. Lipo-LOX: phlogosis 30%. Lipo-EPI: phlogosis 15%. Free EPI: phlogosis 15%. Lipo-EPI-LOX : phlogosis 5%. Scale bar is 400 µm.