Table 2.
Compound | Concentrations (μg/mL) | Percent AChE (mean ± SEM) | AChE IC50 (μg/mL) | Percent BChE (mean ± SEM) | BChE IC50 (μg/mL) |
---|---|---|---|---|---|
V | 1000 | 83.4 ± 0.5∗∗∗ | 80 | 83.2 ± 1.1∗∗∗ | 80 |
500 | 74.1 ± 0.9∗∗∗ | 72.6 ± 1.3∗∗ | |||
250 | 65.9 ± 1.4∗∗∗ | 64.9 ± 0.1∗∗∗ | |||
125 | 56.1. ± 1.4∗∗ | 55.9 ± 1.0∗∗ | |||
62.5 | 48.2 ± 1.4∗∗∗ | 48.1 ± 1.9∗ | |||
VI | 1000 | 80.7 ± 1.1∗∗ | 90 | 79.8 ± 1.4∗∗ | 91 |
500 | 71.2 ± 1.8∗∗ | 71.1 ± 1.6∗∗ | |||
250 | 62.1 ± 2.0∗∗ | 61.4 ± 0.3∗∗∗ | |||
125 | 54.7. ± 1.6∗∗∗ | 53.5 ± 1.6∗∗ | |||
62.5 | 47.2 ± 1.5∗∗∗ | 47.0 ± 1.1∗∗ | |||
VII | 1000 | 80.1 ± 1.2∗∗ | 89 | 80.0 ± 1.1∗∗ | 90 |
500 | 71.5 ± 1.6∗∗ | 71.1 ± 0.8∗∗ | |||
250 | 62.3 ± 1.1∗∗ | 62.1 ± 0.0∗∗∗ | |||
125 | 54.1. ± 1.2∗∗∗ | 53.4 ± 1.1∗∗ | |||
62.5 | 47.8 ± 1.3∗∗∗ | 47.2 ± 1.2∗∗ | |||
Galantamine | 1000 | 92.1 ± 1.0 | 40 | 92.0 ± 0.8 | 43 |
500 | 82.3 ± 1.2 | 81.8 ± 1.4 | |||
250 | 73.4 ± 0.5 | 71.8 ± 1.5 | |||
125 | 64.2. ± 1.2 | 64 .0 ± 1.2 | |||
62.5 | 55.6 ± 2.6 | 54.1 ± 1.0 |
Data presented as mean ± SEM; Values differ significantly compared to the positive control, ns: P > 0.05∗: P < 0.05, ∗∗∗: P < 0.001, n = 3.